What Strategies Can Mitigate Unwanted Immunogenicity?
To mitigate unwanted immunogenicity, researchers can employ several strategies:
Surface Shielding: Coating nanoparticles with biocompatible materials such as PEG (polyethylene glycol) can help prevent recognition by the immune system. Targeted Delivery: Functionalizing nanoparticles with targeting ligands can direct them to specific cells or tissues, reducing the likelihood of unintended immune activation. Controlled Release: Designing nanoparticles for controlled release of their payload can minimize the initial immune response and reduce systemic exposure. Biocompatible Materials: Using materials that are known to be biocompatible can help reduce the likelihood of an adverse immune response.
