What Strategies Are Used to Overcome Biological Barriers?
Several strategies have been developed to enhance the penetration of nanoparticles through biological barriers. These include:
Surface Modification: Functionalizing the surface of nanoparticles with ligands that can target specific receptors on cells can enhance their uptake and transport. Size Reduction: Reducing the size of nanoparticles can improve their ability to penetrate tight junctions and cellular membranes. Use of Carriers: Encapsulating nanoparticles within liposomes or other biocompatible carriers can help them bypass biological barriers and reach their target sites. Stimuli-Responsive Systems: Designing nanoparticles that respond to specific stimuli (e.g., pH, temperature) can help them release their payloads at the desired location.
