What is Cryo-Electron Microscopy (Cryo-EM) and its significance?
Cryo-Electron Microscopy (Cryo-EM) is a technique where samples are rapidly frozen to preserve their natural structure and imaged using electron microscopy. Cryo-EM has become a critical tool in structural biology, allowing scientists to visualize biological macromolecules and complexes at near-atomic resolution without the need for crystallization. This method has provided insights into the function and mechanism of various biomolecular machines.