What Challenges Exist in Achieving Immune Tolerance?
Despite the promising strategies, several challenges remain:
- Complexity of the Immune System: The immune system is highly complex and can vary significantly between individuals. This makes it difficult to predict and control immune responses to nanoparticles. - Long-term Effects: There is limited understanding of the long-term effects of immune tolerance strategies. Continuous exposure to immune-modulating agents may lead to unforeseen consequences. - Regulatory Hurdles: Ensuring that immune-tolerant nanoparticles are safe and effective requires rigorous testing and regulatory approval, which can be time-consuming and expensive.
