There are primarily two types of selective targeting: passive and active targeting.
Passive Targeting Passive targeting takes advantage of the Enhanced Permeability and Retention (EPR) effect, where nanoparticles naturally accumulate in tumor tissues due to their leaky vasculature and poor lymphatic drainage. This method does not require specific interactions between the nanoparticles and target cells.
Active Targeting Active targeting involves functionalizing nanoparticles with molecules that specifically bind to receptors or antigens on the target cells. This method enhances the specificity and uptake of nanoparticles by the target cells, offering a more precise treatment approach.
