There are several methods used for genotoxicity testing, including:
1. In Vitro Tests: These involve testing on cell cultures and are commonly used for initial screening due to their cost-effectiveness and ease of use. Examples include the Ames test, the Comet assay, and the Micronucleus test. 2. In Vivo Tests: These involve testing on live animals and provide more comprehensive data about the genotoxic effects of nanomaterials in a whole organism. Common in vivo tests include the Rodent Bone Marrow Micronucleus test and the Transgenic Rodent Assay. 3. In Silico Models: These use computer simulations to predict genotoxicity based on the chemical structure of nanomaterials. Although still under development, they offer a promising complementary approach to traditional testing methods.
