Despite the advantages, signal enhancement techniques have several limitations:
1. Complexity and Cost: Advanced techniques such as SERS and the use of quantum dots often involve complex synthesis processes and are expensive. 2. Stability: Enhanced signals may not be stable over long periods, leading to issues in reproducibility and reliability. 3. Interference: Enhanced signals can sometimes be affected by background noise or other interfering signals, which can complicate data interpretation. 4. Scalability: Many signal enhancement techniques are difficult to scale up for industrial applications, limiting their widespread use.
