1. Complexity: The setup and optimization of MgFFF systems can be complex, requiring specialized knowledge and equipment. 2. Magnetic Property Dependency: The effectiveness of MgFFF is highly dependent on the magnetic properties of the nanoparticles, which may limit its applicability for non-magnetic particles. 3. Cost: The equipment and materials required for MgFFF can be expensive, which may be a barrier for some research groups or industries.