Several parameters need to be evaluated during safety testing:
1. Size and Shape: The physical dimensions of nanomaterials can influence their biological interactions. 2. Surface Chemistry: The chemical composition of the nanomaterial's surface plays a critical role in toxicity. 3. Solubility: How well nanomaterials dissolve in different environments impacts their behavior in biological systems. 4. Agglomeration: The tendency of nanomaterials to clump together can affect their interaction with cells and tissues.