What Are the Challenges in Using Endocytosis for Drug Delivery?
While endocytosis offers a pathway for nanoparticle delivery, several challenges persist:
Endosomal Escape: Nanoparticles must escape the endosome to avoid degradation by lysosomal enzymes. Target Specificity: Ensuring that nanoparticles target the correct cell types to minimize off-target effects. Biocompatibility: Nanoparticles must be biocompatible to avoid adverse immune responses.
