Despite their promising properties, PQDs face several challenges: 1. Stability: PQDs are prone to degradation when exposed to moisture, oxygen, and light. Developing methods to enhance their stability is crucial for their practical applications. 2. Toxicity: Many PQDs contain lead, raising environmental and health concerns. Research is ongoing to develop lead-free PQDs with similar optoelectronic properties. 3. Scalability: Producing high-quality PQDs on a large scale remains a challenge. Developing scalable synthesis methods is essential for commercial applications.