Despite its advantages, PPTT faces several challenges: 1. Delivery: Efficient delivery of nanoparticles to the tumor site remains a significant hurdle. Various strategies, including targeting ligands and surface modifications, are being explored to improve targeting efficiency. 2. Heat Dissipation: Ensuring that the generated heat is confined to the tumor site without affecting surrounding tissues is critical. 3. Regulatory Approval: The translation of PPTT from laboratory research to clinical practice requires rigorous testing and regulatory approvals.
