Despite their potential, SLNs face several challenges:
1. Particle Size and Stability: Maintaining a uniform particle size and stability over time can be challenging and requires precise control of the synthesis process. 2. Drug Loading Capacity: The capacity to load drugs into SLNs can be limited, especially for hydrophilic drugs. 3. Scale-Up: Scaling up the production of SLNs from the laboratory to industrial levels while maintaining quality and consistency is a complex task. 4. Regulatory Hurdles: The regulatory approval process for SLNs can be rigorous, requiring extensive safety and efficacy data.
