Despite their advantages, there are several challenges associated with the use of LNPs. One of the primary challenges is the potential for immunogenicity, where the body's immune system recognizes the LNPs as foreign and mounts an immune response. Additionally, large-scale production and consistent quality control of LNPs can be technically demanding. Stability during storage and transport is another critical issue that needs to be addressed to ensure the efficacy of LNP-based therapeutics.
