1. Sensitivity: The TGR assay is highly sensitive to low levels of mutagenic agents, making it ideal for detecting the subtle genetic changes that may be induced by nanoparticles. 2. Specificity: It specifically targets mutations in the reporter gene, allowing for precise identification of genetic alterations. 3. Relevance: By using whole animals, the assay provides a more comprehensive understanding of how nanomaterials interact with biological systems compared to in vitro methods.
