Drexler's contributions to nanotechnology are numerous and groundbreaking. He is perhaps best known for his book "Engines of Creation: The Coming Era of Nanotechnology," published in 1986. This work popularized the concept of molecular assemblers—hypothetical machines capable of manipulating individual atoms to create virtually any structure. His subsequent book, "Nanosystems: Molecular Machinery, Manufacturing, and Computation," provides a more technical and detailed overview of the principles underlying molecular manufacturing.