A comprehensive prior art search in nanotechnology involves several key steps: 1. Define the Scope: Clearly understand the scope of your invention, including its technical specifications and applications. 2. Use Patent Databases: Utilize global patent databases such as the USPTO, EPO, and WIPO to search for existing patents. 3. Search Scientific Literature: Explore academic journals, conference papers, and research databases like IEEE Xplore and PubMed. 4. Leverage Keywords and Classifications: Use relevant keywords and patent classifications to narrow down search results. 5. Consult Experts: Engage with patent attorneys or experts in nanotechnology to validate your findings.