Achieving prolonged circulation time involves several strategies:
Surface modification: Coating nanoparticles with hydrophilic polymers like polyethylene glycol (PEG) can help evade the immune system. Particle size and shape: Optimizing the size and shape of nanoparticles can influence their circulation time and biodistribution. Zeta potential: Controlling the surface charge of nanoparticles can minimize opsonization and subsequent clearance by the immune system. Stealth technology: Utilizing biomimetic approaches, such as cloaking nanoparticles with cell membranes, can enhance circulation time.
