The formation of the protein corona can impact the nanoparticles in several ways: 1. Stability: It can enhance the stability of nanoparticles by preventing aggregation. 2. Cell Uptake: The protein corona can mediate the recognition and uptake of nanoparticles by cells, influencing their internalization and trafficking. 3. Immune Response: The corona can mask the nanoparticles, reducing their immunogenicity, or alternatively, it can elicit an immune response depending on the composition of the adsorbed proteins.
