How Does PEGylation Affect Nanoparticle Properties?
PEGylation affects the physical and chemical properties of nanoparticles in several ways:
Increased Stability: PEG chains form a hydrophilic shell around nanoparticles, preventing agglomeration and enhancing colloidal stability. Reduced Immunogenicity: The hydrophilic nature of PEG reduces protein adsorption and immune recognition, thereby minimizing immune response. Enhanced Solubility: PEGylation improves the solubility of hydrophobic nanoparticles in aqueous environments. Tunable Surface Properties: Functional groups on PEG can be tailored to attach specific ligands for targeted delivery.