Nanotechnology enhances solubility through several mechanisms: - Particle Size Reduction: Reducing the particle size to the nanoscale increases the surface area-to-volume ratio, which improves dissolution rates. - Nanosuspensions: These are submicron colloidal dispersions of nanoparticles that increase the solubility of poorly soluble drugs. - Nanocrystals: These are pure drug particles with a crystalline nature, providing a high degree of solubility and bioavailability. - Use of Nanocarriers: Nanocarriers such as liposomes, micelles, and dendrimers can encapsulate hydrophobic drugs, enhancing their solubility in aqueous environments.
