Nanotechnology improves permeation through several mechanisms:
Size and Surface Properties: Nanoparticles can be engineered to have an optimal size and surface charge that enhance their ability to cross biological barriers. Targeted Delivery: Functionalizing nanoparticles with specific ligands allows them to target and bind to receptors on cellular surfaces, facilitating entry. Controlled Release: Nanocarriers can be designed to release their payload in a controlled manner, increasing the efficiency of drug delivery. Penetration Enhancers: Certain nanomaterials can act as penetration enhancers, temporarily disrupting the barrier to allow for increased permeation.
