The working principle of chromatography with nanomaterials remains largely the same as with other substances. However, the techniques and columns used may be specialized to handle the unique properties of nanoparticles. For example, Size-Exclusion Chromatography (SEC) is often used to separate nanoparticles based on their size. In general, the sample containing nanomaterials is introduced into the chromatography system, where it interacts with a stationary phase and a mobile phase. The different components of the sample move at different rates, leading to their separation. Detectors then identify and quantify these separated components.
