Nuclear agents typically operate by crossing the nuclear membrane to deliver their payload directly to the cell's nucleus. This can be achieved through several mechanisms:
Active Targeting: Using ligands or antibodies that bind specifically to nuclear receptors. Passive Diffusion: Leveraging the small size of nanoparticles to diffuse through nuclear pores. Nuclear Localization Signals (NLS): Incorporating peptide sequences that direct nanoparticles to the nucleus.
