Nano manipulators operate using a combination of mechanical, electrical, and optical systems. They typically incorporate advanced mechanisms such as piezoelectric actuators, which allow for movement in the nanometer range. The control system for these devices often utilizes computational algorithms to ensure precise manipulation and positioning. Feedback mechanisms, such as atomic force microscopy (AFM) or scanning tunneling microscopy (STM), are also integral to the operation, providing real-time data to adjust the manipulator's actions.