The working principle of nano cantilevers is based on their ability to bend or vibrate in response to external forces. When a force is applied at the free end of the cantilever, it causes the structure to deflect. This deflection can be measured with high precision using techniques such as laser interferometry or capacitive sensing. In addition, nano cantilevers can be coated with specific materials to make them sensitive to particular substances, enabling their use in chemical sensing and biosensing.