Polydispersity: Nanoparticle samples often contain particles of various sizes, making it difficult to determine an accurate size distribution.
Sample
preparation: The process of preparing samples for measurement can sometimes alter the size distribution.
Aggregation: Nanoparticles tend to aggregate, which can complicate the measurement process.
Instrument
limitations: Each technique has its own limitations in terms of resolution, sensitivity, and the range of sizes it can measure.
Drug delivery: Uniform size distribution ensures consistent drug release and improves therapeutic efficacy.
Catalysis: The surface area-to-volume ratio, which is size-dependent, influences the catalytic activity.
Imaging: In medical imaging, size distribution affects the resolution and signal strength of imaging agents.
Environmental applications: In environmental remediation, size distribution affects the reactivity and mobility of nanoparticles.
