Liquid chromatography (LC) - Nanotechnology

What is Liquid Chromatography?

Liquid Chromatography (LC) is a separation technique that involves the partitioning of compounds in a mixture between a liquid mobile phase and a stationary phase. It is widely used for separating, identifying, and quantifying components in complex mixtures.

How is LC Applied in Nanotechnology?

In Nanotechnology, LC is utilized to characterize and purify nanomaterials. It helps in separating nanoparticles based on their size, shape, and surface properties, which is crucial for applications in drug delivery, diagnostics, and electronics.

What Types of LC are Used in Nanotechnology?

Several types of LC are used in nanotechnology, including:

High-Performance Liquid Chromatography (HPLC): Provides high resolution and is used for the precise separation of nanoparticles.
Size-Exclusion Chromatography (SEC): Separates particles based on their size and is often used for polymeric nanoparticles.
Ion-Exchange Chromatography (IEC): Separates nanoparticles based on their charge and is useful for analyzing ionic nanomaterials.

What Are the Advantages of Using LC in Nanotechnology?

LC offers several advantages in the field of nanotechnology:

High Resolution: Allows for the precise separation of nanoparticles, which is critical for characterization.
Versatility: Can be adapted to separate a wide range of nanomaterials with different properties.
Quantification: Provides accurate quantification of nanoparticle concentrations.

What Are the Challenges of Using LC in Nanotechnology?

Despite its advantages, there are some challenges associated with using LC in nanotechnology:

Sample Preparation: Nanomaterials often require complex sample preparation to prevent aggregation.
Column Compatibility: Not all LC columns are suitable for nanoparticle analysis, requiring specialized columns.
Detection Sensitivity: Detecting nanoparticles at very low concentrations can be challenging.

Future Directions

The use of LC in nanotechnology is expected to grow with advancements in column technology and detection methods. Innovations such as multidimensional chromatography and coupled techniques (e.g., LC-MS) will further enhance the ability to analyze complex nanoparticle systems.

Relevant Publications

Quantification of treprostinil concentration in rat and human using a novel validated and rapid liquid chromatography-tandem mass spectrometry method: Experimental and clinical applications in ischemia-reperfusion injury.

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Comparative study between Salkowski reagent and chromatographic method for auxins quantification from bacterial production.

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Er-Dong-Xiao-Ke decoction regulates lipid metabolism via PPARG-mediated UCP2/AMPK signaling to alleviate diabetic meibomian gland dysfunction.

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Abscisic acid for acute respiratory distress syndrome therapy by suppressing alveolar macrophage pyroptosis via upregulating acyloxyacyl hydrolase expression.

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AI-driven discovery of blood xenobiotic biomarkers in neovascular age-related macular degeneration using iterative random forests.

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POF-based biosensors for cortisol detection in seawater as a tool for aquaculture systems.

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Novel polyarylether nitrile/layered bimetallic oxide/2-Methylimidazole composite membrane for efficient synergistic adsorption and degradation of organic pollutants under visible light.

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Cancer therapeutic potential of hovetrichoside C from Jatropha podagrica on apoptosis of MDA-MB-231 human breast cancer cells.

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Pharmacokinetic study and neuropharmacological effects of Atractylenolide Ⅲ to improve cognitive impairment via PI3K/AKT/GSK3β pathway in intracerebroventricular-streptozotocin rats.

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Maternal exposure to polycyclic aromatic hydrocarbons during pregnancy and timing of pubertal onset in a longitudinal mother-child cohort in rural Bangladesh.

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Proteomic Characterization of Human Placenta: Insights into Potential Therapeutic Applications for Osteoarthritis.

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Metformin drugs under simulated gastric conditions can generate high nitrite-dependent levels of N-nitrosodimethylamine.

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Comprehensive characterization of bacterial glycoconjugate vaccines by liquid chromatography - mass spectrometry.

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Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models.

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Executive function impairment is associated with low serum vitamin D levels in children with epilepsy.

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N,N-dimethylpentylone poisoning: Clinical manifestations, analytical detection, and metabolic characterization.

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Multi-residue determination of biocides in dairy products and slurry feed using QuEChERS extraction and liquid chromatography combined with high resolution mass spectrometry (LC-ESI-QOrbitrap™-MS).

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Spatial proteomics of skeletal muscle using thin cryosections reveals metabolic adaptation at the muscle-tendon transition zone.

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Role of the Abcg2 transporter in plasma, milk, and tissue levels of the anthelmintic monepantel in mice.

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An integrated LC-MS/MS platform for noninvasive urinary nucleus acid adductomics: A pilot study for tobacco exposure.

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