Fibronectin - Nanotechnology

What is Fibronectin?

Fibronectin is a high-molecular-weight glycoprotein found in the extracellular matrix and plasma. It plays a crucial role in cell adhesion, growth, migration, and differentiation. In the context of Nanotechnology, fibronectin's ability to interact with various cell surface receptors makes it a valuable component for bioengineering applications.

How is Fibronectin Used in Nanotechnology?

Fibronectin is often employed in nanotechnology to enhance the biocompatibility of nanomaterials. It can be immobilized on the surface of nanoparticles, nanofibers, and nanosensors to improve cellular interactions and promote tissue regeneration. Its integrin-binding domains facilitate cell attachment and signal transduction, making it ideal for biomedical applications.

What are the Applications of Fibronectin-Coated Nanomaterials?

Fibronectin-coated nanomaterials have a wide range of applications, including:

Tissue Engineering: Enhances the formation of extracellular matrix and supports cell growth and differentiation.
Drug Delivery Systems: Improves the targeting and uptake of drug-loaded nanoparticles by specific cells.
Biosensors: Increases the sensitivity and specificity of nanosensors for detecting biomolecules.
Wound Healing: Promotes cell migration and proliferation at the wound site, accelerating the healing process.

What are the Challenges in Using Fibronectin in Nanotechnology?

Despite its advantages, there are several challenges in using fibronectin in nanotechnology:

Stability: Maintaining the stability and functionality of fibronectin when immobilized on nanomaterials can be challenging.
Cost: High production costs of recombinant fibronectin can limit its widespread use.
Scalability: Developing scalable methods for coating nanomaterials with fibronectin remains a technical hurdle.

Future Directions

Future research in fibronectin and nanotechnology aims to address current challenges and expand its applications. Advanced techniques in synthetic biology and material science are being explored to enhance the stability, functionality, and production efficiency of fibronectin-coated nanomaterials. Additionally, emerging fields like nanomedicine and regenerative medicine are likely to benefit significantly from these advancements.

Relevant Publications

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Dapagliflozin dampens liver fibrosis induced by common bile duct ligation in rats associated with the augmentation of the hepatic Sirt1/AMPK/PGC1α/FoxO1 axis.

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Integrin Mechanosensing relies on Pivot-clip Mechanism to Reinforce Cell Adhesion.

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snRNA-seq of human cutaneous neurofibromas before and after selumetinib treatment implicates role of altered Schwann cell states, inter-cellular signaling, and extracellular matrix in treatment response.

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Novel Small Molecule ROCK2 Inhibitor GNS-3595 Attenuates Pulmonary Fibrosis in Preclinical Studies.

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Retraction Note: The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway.

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Fusobacterium nucleatum-infected periodontitis promotes renal interstitial fibrosis in rats through the TGF-β/SMAD2/3 and β-catenin signaling pathways.

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Gene Profiling of Circular RNAs in Keloid-prone Individuals and ceRNA Network Construction During Wound Healing.

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EBV-positive glycoproteins associated with nasopharyngeal carcinoma.

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Osteogenic Differentiation Potential of iMSCs on GelMA-BG-MWCNT Nanocomposite Hydrogels.

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CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis.

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GSK3 inhibition reduces ECM production and prevents age-related macular degeneration-like pathology.

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Ethyl Pyruvate Decreases Collagen Synthesis and Upregulates MMP Activity in Keloid Fibroblasts and Keloid Spheroids.

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Expression and Clinicopathological Significance of Extracellular Matrix Remodeling Markers in Esophageal Squamous Carcinoma.

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Identification of Regulatory RNA-Binding Proteins Associated with Immune Infiltration in Laryngeal Squamous Cell Carcinoma.

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