What Strategies are Used to Minimize Immune System Rejection?
Several strategies have been developed to reduce immune system rejection of nanoparticles:
Surface Modification: Coating nanoparticles with polyethylene glycol (PEG) or other biocompatible materials can make them less recognizable to the immune system. Size and Shape Optimization: The size and shape of nanoparticles can be engineered to evade immune detection. Smaller particles and certain shapes can circulate longer in the bloodstream. Biomimicry: Designing nanoparticles that mimic naturally occurring particles can help them evade the immune system. For example, liposomes and exosomes are often used for drug delivery. Immune Suppression: In some cases, temporary suppression of the immune system may be employed to allow nanoparticles to perform their intended function.
