Tetrazine Trans Cyclooctene Ligation (TCO) is a highly specific and efficient bioconjugation reaction used primarily in chemical biology and nanotechnology. This reaction involves a [tetrazine]() and a trans-cyclooctene (TCO) group, forming a stable covalent bond. The reaction is known for its rapid kinetics and bioorthogonality, meaning it can occur in living systems without interfering with native biochemical processes.
