What Factors Influence LDH Release in Nanotechnology?
Several factors can influence LDH release when cells interact with nanoparticles. These include:
1. Particle Size and Shape: Smaller particles or those with sharp edges are more likely to penetrate cell membranes and cause damage. 2. Surface Charge: Positively charged nanoparticles tend to interact more strongly with cell membranes, leading to increased LDH release. 3. Concentration: Higher concentrations of nanoparticles generally result in greater cytotoxicity and higher levels of LDH release. 4. Surface Functionalization: Modifying the surface of nanoparticles with biocompatible coatings can reduce their cytotoxic effects.
