Several factors influence the bio distribution of nanoparticles, including:
Size: Smaller particles tend to circulate longer and can penetrate tissues more easily. Shape: Rod-shaped nanoparticles may distribute differently compared to spherical ones. Surface Chemistry: Surface modifications, such as PEGylation, can improve stability and circulation time. Charge: Positively charged particles may interact strongly with cell membranes, affecting their distribution. Hydrophobicity: Hydrophobic particles may accumulate in the liver and spleen.
