What Factors Affect the Distribution of Nanoparticles?
Several factors influence the distribution of nanoparticles within a biological system: 1. Size and Shape: Smaller nanoparticles generally have a wider distribution as they can traverse cellular barriers more easily. 2. Surface Properties: Surface charge and functionalization affect how nanoparticles interact with biological molecules and cells. 3. Solubility: Hydrophilic nanoparticles may distribute differently compared to hydrophobic ones. 4. Protein Corona Formation: The adsorption of proteins onto the surface of nanoparticles can alter their biokinetics.
