Several mechanisms are employed for controlled release, including: 1. Diffusion: Drugs diffuse through the nanoparticle matrix at a controlled rate. 2. Degradation: The nanoparticle matrix degrades over time, releasing the drug. 3. Swelling: Nanoparticles swell in response to environmental changes, such as pH, releasing the drug. 4. Targeted Triggers: Environmental stimuli like light, ultrasound, or magnetic fields can trigger drug release from nanoparticles.