Toxicity and Environmental Impact: The toxicity of nanoparticles is not fully understood, leading to concerns about their impact on human health and the environment. Regulatory Challenges: Existing regulatory frameworks are often inadequate for addressing the unique challenges posed by nanomaterials, leading to a lack of standardized regulations. Economic Viability: The cost of producing nanomaterials can be high, raising questions about their economic feasibility for large-scale applications. Long-term Effects: Long-term studies on the effects of nanomaterials are limited, creating uncertainty about their sustainability and long-term impact.