bioorthogonal click reactions

What are the Key Types of Bioorthogonal Click Reactions?

Several key types of bioorthogonal click reactions are widely used in nanotechnology:

Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC): This reaction is known for its high efficiency and selectivity, but the required copper catalyst can be toxic to cells.
Strain-Promoted Azide-Alkyne Cycloaddition (SPAAC): This reaction does not require a catalyst and is more biocompatible, making it suitable for in vivo applications.
Tetrazine-Trans-Cyclooctene Ligation (TCO): Known for its extremely fast reaction kinetics, this ligation is ideal for dynamic biological systems.
Inverse Electron-Demand Diels-Alder (IEDDA) Reaction: This reaction is also rapid and bioorthogonal, facilitating the functionalization of nanomaterials under physiological conditions.

Frequently asked queries:

What are Bioorthogonal Click Reactions?

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What are the Key Types of Bioorthogonal Click Reactions?

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