What are the Key Features of Effective Endosome Disruptive Peptides?
Effective endosome disruptive peptides typically have several key features:
Amphipathicity: This property allows the peptides to interact with both hydrophilic and hydrophobic regions of the endosomal membrane. pH Sensitivity: These peptides often have a pH-sensitive component that activates in the acidic environment of the endosome, enhancing their disruptive capabilities. Biocompatibility: The peptides should be non-toxic and biocompatible to ensure they do not harm normal cellular functions.
