1. Fabrication Complexity: Manufacturing nanoscale JFETs involves sophisticated techniques that can be cost-prohibitive and complex. 2. Material Limitations: At the nanoscale, the properties of materials can change, potentially affecting the performance and reliability of the JFET. 3. Heat Dissipation: Managing heat in nanoscale components is more challenging, which could impact the longevity and performance of the device. 4. Quantum Effects: At very small scales, quantum mechanical effects can become significant, potentially complicating the behavior of the transistor.