1. Scalability: Producing nanomaterials on a large scale while maintaining their unique properties can be difficult. 2. Cost: The processes involved in optimizing materials can be expensive, which may limit their commercial viability. 3. Stability: Some nanomaterials may degrade over time, losing their optimized properties. 4. Safety and Environmental Concerns: The long-term effects of nanomaterials on health and the environment are still not fully understood.