What Are Some Strategies to Minimize Non-Specificity?
Several strategies can be employed to reduce non-specificity: 1. Surface Modification: Coating nanoparticles with polyethylene glycol (PEG) or other biocompatible materials can reduce protein adsorption and non-specific binding. 2. Targeting Ligands: Attaching specific targeting ligands such as antibodies or peptides to the surface of nanoparticles can enhance specificity to target cells or tissues. 3. Size and Shape Optimization: The size and shape of nanoparticles can be optimized to minimize non-specific interactions and improve target specificity.
