In vivo studies involve experiments conducted within a living organism, such as animals or humans. These studies are critical for understanding the biological effects of nanomaterials in a more realistic and complex environment.
Advantages of In Vivo Studies 1. Realistic Biological Interactions: In vivo studies provide insights into how nanomaterials interact within a living system, including their biodistribution and metabolism. 2. Comprehensive Data: These studies can offer comprehensive data on the efficacy and potential side effects of nanomaterials.
Limitations of In Vivo Studies 1. Ethical Concerns: In vivo studies often raise ethical issues, particularly when involving animal or human subjects. 2. High Cost and Time-consuming: These studies are generally more expensive and time-consuming compared to in vitro studies. 3. Variability: Biological variability can complicate data interpretation and reproducibility.
