Achieving organ specificity involves several strategies: 1. Surface Modification: Nanoparticles can be functionalized with specific ligands that bind to receptors on the target organ or tissue. 2. Shape and Size: The size and shape of nanoparticles influence their biodistribution and accumulation in specific organs. 3. Magnetic Guidance: Magnetic nanoparticles can be directed to specific sites using external magnetic fields. 4. pH Sensitivity: Some nanoparticles are designed to release their cargo in response to the acidic environment of certain tissues.
