Lattice mismatch is typically quantified by the difference in lattice constants between the two materials. This can be expressed as a percentage, calculated using the formula: Mismatch (%) = [(a1 - a2) / a2] * 100 where a1 and a2 are the lattice constants of the two materials. Advanced techniques like X-ray diffraction and transmission electron microscopy are often used to measure lattice constants and analyze the extent of mismatch.