Enhanced specificity can be achieved through several methods: 1. Surface Functionalization: Modifying the surface of nanoparticles with specific ligands that bind to target molecules or cells. 2. Shape and Size Control: Engineering the shape and size of nanomaterials to optimize their interaction with specific biological structures. 3. Use of Biomolecules: Conjugating nanoparticles with antibodies, peptides, or other biomolecules that have a high affinity for target cells or proteins.