Targeted delivery involves directing antibiotics specifically to the site of infection, minimizing exposure to healthy tissues. This can be achieved through various mechanisms:
Passive targeting: Utilizing the enhanced permeability and retention (EPR) effect, where nanoparticles accumulate in inflamed or infected tissues due to leaky vasculature. Active targeting: Functionalizing nanoparticles with ligands or antibodies that bind to specific receptors on bacterial cells, ensuring precise delivery.
