SP-ICP-MS involves introducing a sample containing nanoparticles into an ICP-MS instrument. The sample is nebulized into a fine aerosol, and individual nanoparticles are ionized in the high-temperature plasma. These ions are then detected by the mass spectrometer, generating signals corresponding to individual particles. The signal intensity is proportional to the mass of the particles, enabling size determination, while the frequency of signals corresponds to the particle concentration.
