In this technique, a hydrophobic compound is dissolved in a water-miscible organic solvent, such as acetone. This solution is then added dropwise into an aqueous phase under continuous stirring. As the organic solvent diffuses into the water, the hydrophobic material precipitates, forming nanoparticles. The key to this process is the rapid diffusion and subsequent precipitation, which ensures the formation of nanoparticles with controlled size and distribution.
