When a nanomaterial is identified as requiring SNUR, the EPA publishes a proposed rule in the Federal Register and allows for public comment. Once finalized, any entity planning to manufacture, process, or use the nanomaterial in the newly designated manner must submit a Significant New Use Notice (SNUN) at least 90 days before commencing the activity. This notice includes detailed information on the chemical identity, use, production volume, exposure, and potential adverse effects. The EPA then reviews the submission and can impose restrictions or require further testing to mitigate risks.
