Redox-sensitive nanomaterials are typically engineered using redox-responsive linkers or incorporating redox-active components. These components undergo chemical changes when exposed to specific redox conditions. For example:
Disulfide bonds can be incorporated into the backbone of a polymer, which will break in the presence of reducing agents, leading to drug release. Metal nanoparticles, such as gold nanoparticles, can be functionalized with redox-responsive ligands that change their binding affinity or conformation, altering the nanoparticles' behavior.
